Plymouth are currently in a tough battle with Sheffield Wed for the league title, the teams share the top spot, but Plymouth have one more game to play, so there are no points to lose now. But Plymouth hardly ever lose points in home games - 13 wins and 1 draw.
Portsmouth are in the middle of the standings, the gap to the promotion zone is too big, the team is clearly behind the other top clubs in the league. In the first round match Bolton managed only in the last seconds to snatch a draw at home, we do not think that they will be able to do the same on the road.
Prediction: Plymouth to win. We recommend the "1 Win" bet, odds 2.07