RB Leipzig remains in the top four despite a slump in recent matches: Werner's side have lost two of their last three matches, including their exit from the Bundesliga Cup to Bayern. Their recent home matches have also been disappointing, with three defeats in five matches (although they did win against Bayern and RB Bayer). Leipzig already beat Wolfsburg 1-0 away in the first half.
Wolfsburg are in 15th place and are experiencing serious attacking problems: they have only five wins this season, and only one in their last six matches. They have lost four of their last five away matches, scoring just two goals. Bauer's side have been winless in their last four away matches against Leipzig, conceding all three.
The difference in class, tournament motivation, and head-to-head record favor the hosts. Leipzig needs to redeem themselves for their cup exit and stay in the Champions League zone. Wolfsburg are unlikely to be able to put up a fight on the road.